Reliable genotyping of the G-20210-A mutation of coagulation factor II (prothrombin).
نویسندگان
چکیده
Coagulation Factor II (Prothrombin), Jan Danneberg, André P. Abbes, Ben J. M. Bruggeman, Henk Engel, Jan Gerrits, and Alexander Martens * (Lab. of Clin. Chem., Twenteborg Hosp., P.O. Box 7600, 7600 SZ, Almelo, the Netherlands; Lab. of Clin. Chem., Sophia Hosp., Dr. CA van Heesweg 2, 8025 AB, Zwolle, the Netherlands; *author for correspondence: fax 031-546-833371, e-mail [email protected])
منابع مشابه
The prothrombin gene variant 20210A in venous and arterial thromboembolism.
Several hereditary disorders affecting coagulation factors have been identified as prothrombotic risk factors. Recently, the prothrombin 20210 A/G mutation has been identified as a second important polymorphism involved in venous thrombosis. This article reviews all published information about this new procoagulant mutation. Our group has been involved in a number of studies about the role and ...
متن کاملInteraction of coagulation defects and cardiovascular risk factors: increased risk of myocardial infarction associated with factor V Leiden or prothrombin 20210A.
BACKGROUND A genetic variation located in the 3'-untranslated region of the prothrombin gene (prothrombin 20210 G-->A) was recently described as a risk factor for venous thrombosis. We examined how the presence of this mutation affected the risk of myocardial infarction in a population-based case-control study. Furthermore, we studied the risk of myocardial infarction associated with the simult...
متن کاملHigh-speed Apolipoprotein E Genotyping and Apoli- Poprotein B3500 Mutation Detection Using Real-time Fluorescence Pcr and Colorimetric Microwell Plate Detection of the Factor V
with the LightCycler. Clin Chem 1999;45:694–6. 15. Hiratsuka M, Agatsuma Y, Mizugaki M. Rapid detection of CYP2C9*3 alleles by real-time fluorescence PCR based on SYBR green. Mol Genet Metab 1999;68:357–62. 16. Aslanidis C, Schmitz G. High-speed apolipoprotein E genotyping and apolipoprotein B3500 mutation detection using real-time fluorescence PCR and melting curves. Clin Chem 1999;45:1094–7. ...
متن کاملSimultaneous genotyping for factor V Leiden and prothrombin G20210A variant by a multiplex PCR-SSCP assay on whole blood.
1. van der Meer FJM, Koster T, Vandenbroucke E, Briet E, Rosendaal FR. The Leiden Thrombophilia Study. Thromb Haemost 1997; 78: 631-5. 2. Ridker PM, Hennekens ChH, Lindpaintner K, Stampfer MJ, Eisenberg PR, Miletich JP. Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men. N Engl J Med 1995; 332: 912-...
متن کاملThe Association between Preeclampsia and Defined Polymorphisms in Prothrombin and Coagulation Factor V Genes
Background & Aims: Preeclampsia is one of the complications of pregnancy and a major cause of maternal mortality. Since, hypercoagulation is one of the risk factors, defined polymorphisms of V and II coagulation factors (G1691A and G20210A) may increase the risk of the disease. Methods: This investigation was performed on blood samp...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Clinical chemistry
دوره 44 2 شماره
صفحات -
تاریخ انتشار 1998